TRITERPENE AND STEROL COMPOUNDS ISOLATED FROM ANODENDRON PANICULATUM (ROXB.) A.DC.
Abstract
Phytochemical study on the aerial parts of Anodendron paniculatum led to the isolation of three triterpenes, including ursolic acid (1), esculentic acid (2), cycloartenol (3), and one sterol, desmosterol (4). Their chemical structures were elucidated on the basis of spectroscopic analyses. The cytotoxicity of the isolated compounds against the growth of human cancer cell lines were evaluated using a sulforhodamin B bioassay. Compounds 1 exhibited moderate cytotoxicity against the LU-1 and MKN-7 cell lines with IC50 values of 44.37 ± 5.40, 30.89 ± 3.60 μg/mL, respectively. Meanwhile, compound 4 possessed moderate cytotoxic effects toward the LU-1, KB, Hep-G2, MKN-7 and SW-480 cell lines with IC50 values ranging from 28.11 ± 1.95 to 41.41 ± 2.31 μg/mL.
Key words: Anodendron paniculatum, ursolic acid, esculentic acid, cycloartenol, desmosterol, cytotoxicity.