CHARACTERISTICS STRUCTURAL MORPHOLOGY OF THE COMPOSITE MATERIALS POLYLACTIC ACID/CHITOSAN/QUININE SULFATE MANUFUCTERING BY MICRO-EMULSION METHOD

  • Hoàng Thanh Đức
  • Nguyễn Thị Thu Trang
  • Nguyễn Anh Tuấn

Abstract

Composite materials polylactic acid/ chitosan contains 10 - 50% quinine sulfate was synthesized
by emulsion method of water/oil/water, aim to study the release of quinine sulfate on composite
materials carrying different quinine sulfate content. Characteristics, structural morphology of the
sample composite materials carry quinine sulfate drug was determined by the method of Fourier
transform infrared spectrum, SEM image and analysis of differential scanning calorimetry. Composite
materials polylactic acid/chitosan/quinine sulfate has heterogeneous structure, two-phase. The base
is polylactic acid, dispersed phase is chitosan and quinine sulphate. The quinine sulfate particles has
small size, combined with chitosan particles, dispersed evenly in polylactic acid phase. Bonding
between phases in composites materials polylactic acid/chitosan/quinine sulfate is the hydrogen
bond between hydroxyl groups of polylactic acid, chitosan and quinine sulfate. The phase interaction
in the composite material is the dipole interaction between the C=N group of quinine sulphate and
the NH2 group of chitosan with the carboxyl group of polylactic acid.
điểm /   đánh giá
Published
2019-09-11
Section
RESEARCH AND DEVELOPMENT