STUDY ON ONE-POT SYNTHESIS OF FELODIPINE USING ALUMINA SULFURIC ACID AS CATALYST
Abstract
Efficient one-pot synthesis of Felodipine using 4 components of 2,3-dichlorobenzaldehyde, ethyl acetoacetate, methyl acetoacetate and ammonium
acetate in the presence of alumina sulfuric acid catalyst (ASA), in methanol, at a
temperature of 70°C, for 5 hours. The procedure reveals advantages including
high yield (90%), an environmentally friendly procedure, short reaction time.
The structure of the obtained product was confirmed by NMR spectroscopic data.
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Published
2019-09-11
Issue
Section
RESEARCH AND DEVELOPMENT