Chemical composition, enantiomeric distribution and larvicidal activity against Aedes aegypti and Aedes albopictus of Piper chaudocanum C. DC. essential oil

Authors

  • Nguyễn Quốc Thông
  • Lê Tấn Cường
  • Ngô Gia Huy
  • Satyal Prabodh
  • Võ Thanh Thương
  • Võ Văn Hòa
  • Nguyễn Thị Thu
  • Nguyễn Hải Phong
  • Huỳnh Văn Chung
  • Nguyễn Huy Hùng
  • Setzer William N.

Keywords

Từ khóa: α-Pinene, β-Pinene, Caryophyllene oxide, Arboviruses

DOI:

https://doi.org/10.26459/hueunijns.v135i1C.8461

Abstract

The essential oil of Piper chaudocanum C. DC. was obtained with a yield of 0.15% (w/w). Identified constituents accounted for 96.0% of the total oil composition, with caryophyllene oxide (28.2%), β-pinene (13.8%), and α-pinene (10.6%) as the major components. Chiral GC-MS analysis, reported for the first time for P. chaudocanum essential oil, revealed that (–)-α-pinene (92.1%), (–)-β-pinene (93.1%), and (–)-limonene (80.2%) were the predominant enantiomers. The essential oil exhibited significant larvicidal activity against Aedes aegypti and Aedes albopictus, with 24-h LC₅₀ values of 37.58 and 38.50 µg/mL, respectively.

Downloads

Download data is not yet available.

References

1. World Health Organization. Increased risk of mosquito borne diseases [Internet]. Geneva: World Health Organization; [cited 2025 Aug 16].

Available from: https://www.who.int/multi-media/details/increased-risk-of-mosquito-borne-diseases

2. Franklinos LH, Jones KE, Redding DW, Abubakar I. The effect of global change on mosquito-borne disease. The Lancet infectious diseases. 2019;19(9):e302-12.

3. World Health Organization. Zika virus disease - India [Internet]. Geneva: World Health Organization; 2025 [cited 2025 Aug 16]. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2025-DON549

4. Pattnaik A, Sahoo BR, Pattnaik AK. Current status of Zika virus vaccines: successes and challenges. Vaccines. 2020;8(2):266.

5. Miresmailli S, Isman MB. Botanical insecticides inspired by plant–herbivore chemical interactions. Trends in plant science. 2014;19(1):29-35.

6. Hai CT, Van Thanh D, Xuan VT, Nam MH, Tam KT. Anticancer activity of Piper chaudocanum essential oils and essential oil-mediated silver nanoparticles. Biochemical Systematics and Ecology. 2023;108:104621.

7. Trinh NB, Satyal P, Ngo GH, Le TT, Vo TT, Nguyen VH, et al. Chemical composition, mosquito larvicidal and molluscicidal activities of Magnolia foveolata leaf essential oil. Biochemical Systematics and Ecology. 2023;109:104666.

8. Van Den Dool HA, Kratz PD. A generalization of the retention index system including linear temperature programmed gas-liquid partition chromatography. Journal of Chromatography A. 1963;11:463-71.

9. Satyal P. Development of GC-MS database of essential oil components by the analysis of natural essential oils and synthetic compounds and discovery of biologically active novel chemotypes in essential oils [Dissertations]. Huntsville: University of Alabama in Huntsville; 2015.

10. Adams RP. Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry (4th Ed). Allured Publishing; 2007.

11. NIST. National Institute of Standards and Technology (2007). Gaithersburg, Maryland (USA): NIST; 2017.

12. Mondello L. FFNSC 3. Shimadzu Scientific Instruments. Columbia, Maryland (USA); 2016.

13. Finney D. Probit Analysis. Cambridge: Cambridge University Press; 2009.

14. Marques AM, Fingolo CE, Kaplan MA. HSCCC separation and enantiomeric distribution of key volatile constituents of Piper claussenianum (Miq.) C. DC. (Piperaceae). Food and Chemical Toxicology. 2017;109:1111-7.

15. Ramírez J, Andrade MD, Vidari G, Gilardoni G. Essential oil and major non-volatile secondary metabolites from the leaves of Amazonian Piper subscutatum. Plants. 2021;10(6):1168.

16. Gilardoni G, Matute Y, Ramírez J. Chemical and enantioselective analysis of the leaf essential oil from Piper coruscans Kunth (Piperaceae), a costal and Amazonian native species of Ecuador. Plants. 2020;9(6):791.

17. Lucia A, Audino PG, Seccacini E, Licastro S, Zerba E, Masuh H. Larvicidal effect of Eucalyptus grandis essential oil and turpentine and their major components on Aedes aegypti larvae. Journal of the American Mosquito Control Association. 2007;23(3):299-303.

18. Cheng SS, Liu JY, Tsai KH, Chen WJ, Chang ST. Chemical composition and mosquito larvicidal activity of essential oils from leaves of different Cinnamomum osmophloeum provenances. Journal of Agricultural and Food Chemistry. 2004; 52(14):4395-400.

19. Cheng SS, Chang HT, Lin CY, Chen PS, Huang CG, Chen WJ, et al. Insecticidal activities of leaf and twig essential oils from Clausena excavata against Aedes aegypti and Aedes albopictus larvae. Pest Management Science: formerly Pesticide Science. 2009;65(3):339-43.

20. Nguyen BV, Thong NQ, Satyal P, Hoan LC, Vi LD, Thuong VT, et al. Chemical composition and larvicidal activity of the essential oil of Alpinia breviligulata (Gagnep.) Gagnep. against two species of Aedes mosquitoes. Natural Product Communications. 2025; 20(3):1934578X251327827.

Published

2026-09-23

Issue

Section

Original Article