Assessment of cardiovascular drug-drug interactions and development of a drug-drug interactions list among outpatients at Long My Health Center, Hau Giang, in 2023

Abstract

Drug-drug interactions (DDIs) are adverse events that frequently occur in clinical practice. Notably, the incidence of cardiovascular DDIs has been observed to be higher compared to other drugs. DDIs may result in severe outcomes, including increased toxicity, diminished therapeutic efficacy, and an elevated risk of hospitalization and mortality. The purpose of this research was to assess the prevalence, severity, pharmacological mechanisms of cardiovascular DDIs and develop a cardiovascular DDIs list among outpatients at Long My Health Center, Hau Giang, in 2023. We conducted a cross-sectional, retrospective study of all cardiovascular prescriptions among outpatients at Long My Health Center, Hau Giang from January 1^st, 2023, to March 31^st, 2023. Criteria for evaluating DDIs involve using three databases: drugs.com (www.drugs.com/drug_interactions.html), medscape (reference.medscape.com/drug-interactionchecker), and micromedex (www.micromedexsolutions.com). The study has successfully built a practical list of clinically significant cardiovascular DDIs using three databases, including 23 pairs, which will be the foundation for future clinical interventions aimed at minimizing the prevalent drug interactions, especially to prevent the occurrence of major severity.