EFFECTS OF ALCOHOL-SOLUBLE COMPONENTS IN SOYMILK RESIDUE ON PLASMA LIPID LEVELS, LIPID DIGESTION AND BODY WEIGHT GAIN IN SWISS MICE

DOI: 10.18173/2354-1059.2025-0061

Tóm tắt

The present study was conducted to examine the effects of alcoholsoluble components (alcohol extract, AE) in soymilk residue (SR) on body weight gain, plasma lipid levels, and lipid digestion in Swiss mice. Aqueous ethanol was used to extract the SR, afterwhich the residue and the supernatant were separated. The supernatant was then dried to produce the AE. Four experimental diets were formulated and designated as CD (control diet), CD+AE20 (CD supplemented with 20 g AE/kg), CD+AE40 (CD supplemented with 40 g AE/kg), and CD+AE60 (CD supplemented with 60 g AE/kg). Six mice (with an initial body weight of 24 g) were distributed into each of eight cages, with two replicate cages per dietary treatment. The experimental mice were fed with the test diets ad libitum for 4 weeks. The results showed that the final body weights of mice fed with AEsupplemented diets were lower than those fed with the control diet, while no differences in feed intake were found among the treatments. Moreover, the AE significantly reduced body weight gain with significant differences observed in mice receiving AE supplementation levels of 40 and 60 g/kg. The mice fed with AE-supplemented diets exhibited lower plasma concentrations of total cholesterol, low-density lipoprotein, and triglyceride as well as lower intestinal total bile acid level and lipase activity, but higher lipid content in feces, compared with those fed with the control diet. These findings indicated that the AE in SR negatively affected the lipid digestion process, therefore reducing plasma cholesterol levels and body weight gain in Swiss mice.