SYNTHESIS OF SOME FLAVONES AND 4-THIOFLAVONES AS POTENT ANTIBACTERIAL AGENTS

Abstract

A series of flavones and thioflavones were synthesized via the chalcone pathway, in which 2'-hydroxyacetophenone is condensed with benzaldehyde derivatives in the medium of potassium hydroxide - methanol at room temperature. The obtained chalcones were treated by iodine in refluxed dimethyl sulfoxide turning into the corresponding flavones. Reaction of flavones and Lawesson's reagent in boiling toluene gave the 4-thioflavones with high yields from 53-76%. All the synthetic compounds were purified by column chromatography and recorded their UV, IR and ¹H-NMR spectra.