NANO - COMPOSITE NZVI/GNPS@TCPP: VẬT LIỆU XANH ỨNG DỤNG CHO CẢM BIẾN ĐIỆN HÓA PHÁT HIỆN CHLORAMPHENICOL TRONG THUỐC NHỎ MẮT

Tóm tắt

Accurate and cost-effective analytical methods for detecting antibiotic residues play a crucial role in ensuring pharmaceutical quality and public safety. In this study, an electrochemical sensor was developed by modifying a glassy carbon electrode (GCE) with zero-valent iron nanoparticles synthesized using Cleistocalyx operculatus leaf extract, in combination with graphene and tetra(4-carboxyphenyl) porphyrin (nZVI/GNPs@TCPP), for the detection of chloramphenicol (CAP) residues in eye drops solutions. The structural and morphological characteristics of the nZVI/GNPs@TCPP nanocomposite were investigated using advanced techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR). The electrochemical behavior of CAP was evaluated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV), providing qualitative detection limit (LOD) of 0.185 μM, quantitative limit (LOQ) of 0.618 μM and sensitivity of 1.580 μA·μM⁻¹·cm⁻².