Combining some natural substances with gelatin – alginat sponges for treatment burn wounds

Abstract

The sponges consisting of gelatin from hydrolysis of collagen and alginat – a polysaccharide from Phaeophyta were established by using EDC as a crosslinking agent. The sponges were combined with some natural substances traditional used for burn treatment such as tamanu oil (from nuts of Calophyllum inophyllum); cajeputi oil (from leaves of Meulaleuca leucadendron); madecassol (from extract of Centella asiatica); turmeric and python fat. Data obtained from testing on mice showed that the coordinated sponges have rather good ability on preventing infection and promoting wound healing compared with control. The sponges combined with mixture of cajeputi oil and madecassol have the best potential for burn treatment.