Characteristics of Collected Umbilical Cord Blood at Hai Phong Medical University Hospital and Vietnam National Institute of Maritime Medicine in 2024

  • Thi Loc Pham
  • Van Hieu Truong
  • Nguyen Mai Anh Do
  • Minh Hoang Tran
  • Thuy Quynh Pham
  • Thi Anh Duong Tran
  • Van Hieu Bui
  • Truong Son Nguyen
  • Van Khai Nguyen
Từ khóa: Umbilical Cord blood,  Cord blood bank, Hematopoietic stem cells, total nucleated cells, cord blood quality.

Tóm tắt

Objective: Determining the characteristics of collected umbilical cord blood (UCB) at Hai Phong Medical University Hospital and the Vietnam National Institute of Maritime Medicine and evaluation of the relationship between risk factors and the volume of UCB in 2024. Materials and Methods: A prospective cross-sectional study was conducted on 172 UCB samples collected between September and November 2024. Results: The average collected UCB volume was 87.6 ± 24.4 ml. Of the 172 samples, 152 (88.4%) met quality standards, while 20 (11.6%) were excluded due to low volume, clot formation, or microbial contamination. Total nucleated cells collected 80.78 ± 49.14 (×10⁷ cell), with 71.7% recovery. Lymphocytes is 48.7 ± 59.5 (×10⁷ cell), recovering 87.4%. Red blood cells are 0.089 ± 0.054 (T/L), with 1.8% recovery. Platelets are 683 ± 351.6 (×10⁷), achieving 55% recovery. Maternal factors such as age, delivery method, and delayed cord clamping influenced UCB quality. In utero collection yielded higher total nucleated cell (TNC) counts and CD34+ cells compared to ex utero methods. Conclusion: the result provide an information for UCB banking and processing, demonstrating effective preservation of high nucleated white blood cells and lymphocytes, eliminates almost all red blood cells, and retains a portion of platelets, making it suitable for regenerative medicine and immunotherapy applications.

điểm /   đánh giá
Phát hành ngày
2025-01-10