Synthesis, characterization and investigation of biological activity of Cu(II), Ni(II) complexes of citronellal and memthone thiosemicarbazones.

Abstract

Two new thiosemicarbazones derived from natural aldehyde and ketone, and their nickel (II), copper(ll) complexes were synthesized and characterized by R,UV·VIS, MS and NMR spectroscopies. The results indicate the formation of 1:2 metal to ligand complexes with empirical formulae [CuL2] and [NiL2] (HL: hiosemicarbazone). The Cu(II) and Ni(II) complexes are four coordinate and square planar geometry in which the ligands behave as bidentate chelating agents in the uninegatively charged form. The biological activity of thiosemicacbazones and complexes against the bacteria.fungi and cancer cell have been tested.