Study on synthesis and transformation of 6-acetyl-5-hydroxy-4-methylcoumarine and 6-acetyl-7-hydroxy-4-methylcoumarine.
Abstract
By the acetylation of resorcinol by acetic acid and ZnCl2 has been obtained 2,4 dihydroxyacetophnone, which in reaction with ethyl acetoacetate to give 6-acetyl-5-hydroxy-4-methylcoumarine or 6-acetyl-7-hydroxy-4-methylcoumarine. By condensation of 6-acetylcoumarines derivatives with aromatic aldehydes have been prepared the series of α, β-unsaturated ketones. Antimicrobial and antifungal activities of these compounds have been investigated. Structure of these products have been determined by IR1H-NMR and MS spectroscopies.