Synthesis, structure and biological activity of some complexes cis-dichloro( safrole)(amine)platinum(II)

Abstract

Three complexes of platinum(II) including cis-[Pt(Saf)(piperridine)Cl2] (P4), cis-[Pt(Saf) (aniline)Cl2] (P5), cis-[Pt(Saf)(o-toluidine)Cl2) (P6) have been synthesized. The structure of the complexes have been determinded by elemental analysis. molar conductivity. API MS, IR. Raman, electronic and ¹H NMR spectra studies. The biological test shown that complexes P4 exhibit antimicrobial activity on Cialbicans, P5 on E. coli bacterium and F. oxysporum. P4 exhibit inhibitor activity on Hep-G2 cancel cell, P6 on Hep-G2 and RD cancel cell at concentration 1.7 3.2 μg/ml.