STUDY ON PREAPRATION OF THE MIXTURE BETWEEN CHITOSAN AND NASAL SPRAYS MADE FROM IDENTITY FLOWER AGERATUM CONYZOIDES L. AS A METHOD OF SINUSITIS TREATMENT

Abstract

Chitosan is a natural polymer obtained by chitin deacetylation. Chitosan
molecules have good physicochemical properties like drug delivery systems. It is
bio-safe, non-toxic, biocompatible and biodegradable polysaccharide. Chitosan
molecules have a controlled size and a narrow size distribution is obtained
through ionization gelation between CS and sodium tripolyphosphate (TPP). In
this paper, we have used H2O2 chitosan short circuit and used TPP to create crosslinking. Suitable structural chitosan is only obtained when the mass ratio of
chitosan / TPP is 6:3. At this rate, when creating a suspension with nasal spray, it is antibacterial, especially for important bacteria in the nasal route: E. coli, M.
catarrhalis, S.aureus.