SYNTHESIS OF NEW C-3 ESTER-LINKED BETULINIC ACID CONJUGATES WITH LAMIVUDINE
Tóm tắt
Betulinic acid and its derivatives display diverse bioactivities, such as anti-inflammatory, antitumor, anti-inflammatory, antibacterial, antimalarial, anticancer, and anti-HIV activities. Betulinic acid possesses three sites that are the most flexible toderivatization, including the C-3 hydroxyl, C-20 alkene, and C-28 carboxylic acid positions. This study aims to design and synthesis of a C-3 betulinic acid derivatives.
Betulinic derivatives were synthesized by using classical esterification or ester - ester exchange reaction. The target product was isolated by using column chromatography. Its structure was determined by combining spectral analysis and comparison with related data.
A new hybrid compound (compound 1c) was successfully synthesized from betulinic acid (BA) and lamivudine (3TC).
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Phát hành ngày
2020-04-17
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