Chemical Composition and Staphylococcus aureus Inhibitory Activity of the Ethanol Extract from Mahonia nepalensis DC.

Abstract

     An investigation was conducted to determine the chemical composition and inhibitory effect against Staphylococcus aureus of Mahonia nepalensis DC. (M. nepalensis) extract. Chemical analysis showed that the extract contained alkaloids, tannins, flavonoids, saponins and terpenoids. The growth of Staphylococcus aureus strain was inhibited by the different extract concentrations. The diameter of inhibition zones varied from 10 to 15 mm for the extract concentrations from 20-40 mg/ml. The MIC, IC50 and MBC values were 0.05; 4.17 and 21.67 mg/ml, respectively. It is, therefore, suggested that the extract from M. nepalensis could be used as an anti-Staphylococcus agent in particular and a promising antibacterial agent in general.