Pathological Characteristics of the Dogs Caused by Care Virus (CDV-768)

Abstract

    Canine distemper (CD) is an acute infectious disease caused by virus in dogs. Results of infecting virus strain Care (CDV-768) for three Berger dog hybrids at 2 months of age a dose 106TCID50/25μl through the eyes, mouth, and nebulization showed that infected dogs showed symptoms of moodiness, fatigue, appetite loss, fever, vomiting, diarrhea, and bloody diarrhea with sketchy notes on the skin, thickening/keratinizing of the soles of the feet. The macroscopic pathological lesions were found mainly in the lungs (pulmonary sectional epidemic, lung incarnate), intestinal hyperemia phenomena, hemorrhage, brain hemorrhage, swollen lymph nodes, liver degeneration, and swollen gallbladder. The microscopic pathological signs included red blood cells inside alveoli, alveolar walls rupture, parenchymal cell degeneration, torn crushed villi, and inflammatory cell infiltration in the brain. Virus concentrated mainly in the lungs, lymph nodes and intestines. The experimental results showed that virus strain Care (CDV-768) was highly virulent and potentially pathogenic for dogs.