INFLUENCE OF INTESTINAL GOBLET CELL BY Eimeria vermiformis INFECTION ON THE EXPULSION OF Nippostrongylus brasiliensis IN CO-INFECTED HOST

Abstract

     Goblet cell plays an important role on expulsion of Nippostrongylus brasiliensis by increase in the number in intestine. In contrast, infection with Eimeria vermiformis lead to decrease goblet cell number. On the other hand, Eimeria vemiformis results in the development of small intestinal Th1-type and infection of Nippostrongylus brasiliensis results on development of Th2-type response. This paper discussed the influence of goblet cell in coinfected host on elimination of Nippostrongylus brasiliensis. For this purpose, Nippostrongylus brasiliensis and Eimeria vermiformis were infected to ICR mice, expulsion of the worm were delayed in co-infected group compare to single infected group and associated with the changes of goblet cell number. The results clearly showed that Eimeria vermiformis infection influenced to the delay of elimination of Nippostrongylus brasiliensis in immune group. Thus, the influence may effect through immune system was suggested.