Study on synthesis and cytotoxic activity of goniotriol, dimer- goniotriol, howiinol A and their precursor

Abstract

The styryl-lactones belong to a group of secondary metabolites commonly isolated from the family Annonaceae. Among them, Howiinol A (12) has shown in vitro cytotoxic effect against the cancer cell line L1210  and  goniotriol (13)  has  shown  in vitro cytotoxic effect against the cancer cell line MCF₇. Recently, we have announced the synthesis of howiinol A. Herein, we report  the  synthesis  of  goniotriol (13) and dimer-goniotriol (14) from precursor 10. Simultaneously, cytotoxic evaluation of these compounds againts several cancer cell lines was performed. One of them, specially, compound 11 has high activity against 4 human cancer cell lines LU-1, HepG₂, KB và MCF₇ with IC₅₀ = 0.53, 0.71, 0.66 and 0.58 µg/ml, respectively.