Study on chemical constituents and biological activities of miliusa sinensis Finet et Gagnep., (Annonaceae)

Abstract

Eleven compounds were isolated from the n-hexane and the ethyl acetate  extracts  of Miliusa sinensis collected in Hoa Binh province. Their structures were elucidated by analysis of MS, NMR spectra and comparison with the published data. They are methoxy flavanones and methylated  flavone:  pinostrobin  (1),  5-hydroxy-7,4’-dimethoxy  flavanone  (2),  5-hydroxy-6,7-dimethoxy  flavanone  (3), 5-hydroxy-7,8-dimethoxy flavanone (4), 3,5-dihydroxy-7,3’,4’-trimethoxyflavone  (5);  two  chalconoids:  pashanone  (6),  dihydropashanone  (7); one triterpene: 24-methylenecycloartane-3β,21-diol (8); an oxoaporphine  alkaloid:  liriodenine (9), and stigmasterol (10), β-sitosterol glucoside (11). The  bioactivities of  the ethyl acetate extract as well as compounds 5 and 9 were reported.