Natural killer cell activity assay of adults with sleep disorders

Abstract

Objective: To describe the peripheral blood natural killer (NK) cell activity in adults with non-organic sleep disorders. Methods: A descriptive study was conducted on 39 adult patients with non-organic sleep disorders. NK cell activity was indirPctly assessed by measuring IFγ cytokine concentration in the serum using ELISA technique after stimulation with Promoca reagent. Results: The average level of NK cell activity was 495.13 ± 389.82 pg/ml. No statistically significant difference in NK activity was found between genders or age groups (p > 0.05). There was no significant correlation between NK activity and peripheral blood leukocyte counts. Conclusion: The NK cell activity of adults with non-organic sleep disorders showed a mild decrease compared to typical reference levels, though not statistically significant. These findings suggest a potential impact of non-organic sleep disorders on the innate immune system, particularly involving NK cells.