Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents

  • Thuy-Duy Thi Nguyen, Anh Vy Truong, Hoang Phuong Tran
  • Thuy-Duy Thi Nguyen, Anh Vy Truong, Hoang Phuong Tran*
Từ khóa: Biginelli reaction, deep eutectic solvents, green catalyst, green chemistry.

Tóm tắt

A straightforward method for the preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by an acidic deep eutectic solvent from choline chloride (ChCl) and phenol via the Biginelli reaction of 2-aminobenzimidazole, ethyl acetoacetate, and aldehydes has been developed under metal- and solvent-free conditions. The desired products were obtained in moderate to good yield (49-79%) and the DESs were known as an economical and environmentally friendly catalyst.

Tác giả

Thuy-Duy Thi Nguyen, Anh Vy Truong, Hoang Phuong Tran

Department of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh city

Thuy-Duy Thi Nguyen, Anh Vy Truong, Hoang Phuong Tran*

Vietnam National University, Ho Chi Minh city

điểm /   đánh giá
Phát hành ngày
2021-09-21
In ra
Số. 3C (2021): SEPTEMBER 2021 . VOLUME 63 NUMBER 3
Chuyên mục
PHYSICAL SCIENCES