ANALYZING THE FREQUENCY OF ANTIMICROBIAL RESISTANCE GENE IN SALMONELLA AND DETERMINING POTENTIAL INHIBITORS OF ANTIBIOTIC RESISTANCE PROTEIN BY VIRTUAL SCREENING

Abstract

Antimicrobial resistance is a global public health concern. Salmonella is one of the microorganisms in which some resistant serotypes have emerged, affecting the food chain. Therefore, research to find new compounds with potential to inhibit antibiotic resistance Salmonella is urgently needed. This study aims to determine the frequency of antibiotic resistance genes appearing in the Salmonella genome isolated in Vietnam and to screen compounds with potential inhibiting antibiotic resistance related protein. Using bioinformatics tools, the analysis results showed that the AAC(6')-Iaa gene has the highest frequency in the studied samples. For virtual screening of bioactive compounds with potential to inhibit antibiotic resistance, molecular docking and pharmacokinetic properties prediction methods are used. The results of the screening process found 4 most potential compounds including KU-0058684, AdipoRon, BPIPP và CID 3447933. These compounds have high affinity to target proteins, suitable pharmacokinetic properties for drug formulation, and can be used as leading compounds in further drug development studies.