COMPARATIVE ASSESSMENT OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF METALLIC ION BASED FORMULATIONS

Abstract

The threat posed by antibiotic resistance has become particularly critical in recent years because multiple and extended resistant bacteria have become more prevalent, leading to more common hard-to-treat infections worldwide. There is an urgent need to develop new antimicrobial agents against drug-resistant strains. The present study aims to investigate the potential of the new formulations including silver (I) nanoparticles as well as copper (II) and zinc (II) chelates in their separated and complex forms in the treatment of infectious diseases. The capacity of metallic ion based systems to suppress the development of microorganism often seen on wounds, such as Gram-negative bacteria (Klebsiella pneumonia ATCC 700603, Pseudomonas aeruginosa ATCC 27853), Gram-positive bacteria (Staphylococcus aureus ATCC 29213), and fungi (Candida albicans ATCC 10231) were evaluated by microdilution assay. We showed the inhibition percentage against each bacterial strain, which can be used to calculate the minimum inhibitory concentration (MIC) of these metal ions formulations. The positive results suggested that these formulas thus could be developed for wound care in therapy.