Assessment of the association between serum HBsAg levels and selected laboratory parameters in patients with chronic hepatitis B

Abstract

Background: Quantitative hepatitis B surface antigen (qHBsAg) has been considered as a useful biomarker for assessing viral replication activity and monitoring disease progression in patients with chronic hepatitis B. Objective: To describe serum qHBsAg levels and investigate the association between qHBsAg, HBV DNA levels, and selected laboratory parameters in patients with chronic hepatitis B. Materials and Methods: A cross-sectional study was conducted on 56 patients with chronic hepatitis B at Hue University of Medicine and Pharmacy Hospital from June 2025 to January 2026. Serum qHBsAg levels were measured using an electrochemiluminescence immunoassay. Patients were categorized according to hepatitis B e antigen (HBeAg) status into HBeAg-positive (n = 31) and HBeAg-negative (n = 25) groups. Results: The median serum qHBsAg level was 3.35 log10 IU/mL (IQR: 2.55 - 4.11). Patients in the HBeAg-