A case report of ectopic Choroid Plexus Papilloma in the cerebellopontine angle and literature review

Abstract

Choroid plexus papillomas (CPPs) are uncommon intracranial benign tumors classified as World Health Organization (WHO)
grade I malignancies and account for 0.4%-1% of all intracranial tumors. In adults, CPPs typically present in the fourth ventricle whereas in children they are identified in lateral ventricle. CPPs arising from extraventricular locations are extremely rare and challenging to diagnose. We report a case of a 41-year-old male with complaint of occipital headache of few weeks duration with occasional visual decreasing. Magnetic resonance imaging revealed a lesion occupying in the left cerebellopontine (CP) angle. Patient underwent surgery with partial tumor resection. Histology showed a tumor composed of papillae lined by cuboidal to columnar epithelium with clear nuclei. The cells showed immuno-reactivity for CK7, glial fibrillary acidic protein (GFAP) whereas immuno-negativity for thyroid transcription factor-1 (TTF-1). The final diagnosis was affirmed ectopic Choroid plexus papilloma. Patient has been continuing to
undergo Gamma radiosurgery and to follow up by clinical presentation and MRI imaging.