Study of serum uric acid concentrations in newly diagnosed type 2 diabetes patients

Tóm tắt

Background: Serum uric acid (SUA) is the final product of purine metabolism in humans. There is increasing evidence that increased SUA is an independent risk factor for impaired fasting glucose (IFG) and type 2 diabetes. In Vietnam, studies on the relationship between SUA and newly diagnosed type 2 diabetes are still quite modest. Objectives: To survey clinical, paraclinical, and SUA characteristics in newly diagnosed type 2 diabetes patients. To evaluate the relationship between SUA and some clinical and paraclinical characteristics in the study patient group. Methoology: Cross-sectional descriptive method, comparison with the control group. Convenient sampling was selected, 64 patients in the newly diagnosed type 2 diabetes group and 64 other samples in the control group. The study was conducted at the Outpatient Department - Hue Central Hospital from March 2023 to November 2023. Results: The rate of increased SUA in patients with newly diagnosed type 2 diabetes was 28.1%. Increased triglyceride (TG) accounted for the highest rate of 65.6%, overweight/obesity and increased total cholesterol (TC) together accounted for 60.9%, central obesity 50.0%, increased LDL-c 47.6%. Decreased HDL-c accounted for the lowest rate of 18.8%. The rate of increased TG, central obesity, overweight/ obesity was higher in the diabetic group than in the control group (p<0.05). The average SUA concentration in patients with newly diagnosed type 2 diabetes was 360.12±103.45μmol/l. Factors SUA, waist circumference, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), blood glucose, HbA1c, TG, HDL-c, non-HDL-c were higher in the study group than in the control group (p < 0.05). SUA concentration in men was higher than in women (p < 0.01). The rate of increased SUA in men was 37.8%, higher than in women by 5.3%. The risk of increased SUA in men was 10.93 times higher than in women (p < 0.01). The older the age group, the higher the uric acid concentration. Factors CT, non-HDL-cholesterol, creatinine, waist circumference, systolic blood pressure, diastolic blood pressure were positively correlated with SUA. Factors HbA1c, glomerular filtration rate were inversely correlated with SUA. The area under the ROC curve shows the accuracy in predicting the possibility of diabetes of TG, HDL-cholesterol, non-HDL-c, UHR, waist circumference, BMI, diastolic blood pressure with statistical significance. Triglyceride ≥ 1.76 mmol/l is an independent risk factor for type 2 diabetes (p < 0.01). Conclusion: Routine assessment of SUA levels is recommended in newly diagnosed type 2 diabetes patients, as hyperuricemia may serve as an important prognostic marker. There are many metabolic diseases co-morbid with increased SUA in patients with newly diagnosed type 2 diabetes.