RISK FACTORS ASSOCIATED WITH PROGRESSION TO ACUTE-ON-CHRONIC LIVER FAILURE IN SEVERE ACUTE EXACERBATION OF CHRONIC HEPATITIS B

Tóm tắt

Hepatitis B virus (HBV) infection is a prevalent and serious infectious disease. Severe acute exacerbation of chronic hepatitis B occurs in 40-50% of patients with chronic hepatitis B, which can progress to acute-on-chronic liver failure (ACLF) when their liver damage worsens. Early diagnosis and treatment play an important role in the survival of patients with ACLF. To investigate risk factors associated with the progression of ACLF in severe acute exacerbation of chronic hepatitis B. A retrospective, cross-sectional study with longitudinal follow-up was conducted on 69 patients with severe acute exacerbation of chronic hepatitis B, conducted at the Department of Gastroenterology, The University of Medicine Center of Ho Chi Minh City from January 2022 to December 2023. Of the 69 patients, 30 (43.5%) progressed to ACLF. Univariate analysis identified a history of compensated cirrhosis (OR = 9.04; 95% CI: 3.0–27.2), spider angiomas (OR = 4.43; 95% CI: 1.54–12.75), palmar erythema (OR = 5.07; 95% CI: 1.75–14.64), lower serum sodium (OR = 1.18; 95% CI: 1.02–1.37), higher total bilirubin (OR = 1.06; 95% CI: 1.01–1.12), and lower serum albumin (OR = 1.29; 95% CI: 1.13–1.47) as significant risk factors for ACLF progression in severe acute exacerbation of chronic HBV. Risk factors associated with the progression of ACLF in severe acute exacerbation of chronic hepatitis B are a history of compensated cirrhosis, spider angiomas, palmar erythema, serum sodium, total bilirubin, and serum albumin. Serum albumin is an independent risk factor.