RESEARCH ON SYNTHESIS OF METRONIDAZOLE ANTIBIOTICS

Abstract

Metronidazole is an antibiotic that is very effective against intestinal infections. For a long time, metronidazole has been used as a medicine to treat amoeba infections, HP bacteria that cause stomach and duodenal ulcers and are a risk of stomach cancer. To synthesize the antibiotic metronidazole, starting from two precursors 2-methyl-1H-imidazole and 2-methyl-5-nitro-imidazole. This article studies the synthesis of the antibiotic Metronidazole to treat gastrointestinal infections. The optimal conditions for the synthesis of Metronidazole have been determined: The molar ratio between 2- methyl-5-nitroimidazole and ethylene chlorhydrin is 1/10. Temperature 128 – 130oC. pH = 9 – 9.5. Time 18 h. Efficiency reached 42.7%. The research results will be the scientific basis for applying to production technology processes and proactively developing medicinal resources in Vietnam.