ASSOCIATION BETWEEN THE MTHFR C677T GENE POLYMORPHISM AND ISCHEMIC STROKE AMONG PATIENTS TREATED AT THAI NGUYEN NATIONAL HOSPITAL
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DOI:
https://doi.org/10.34238/tnu-jst.15104Abstract
Stroke in general and ischemic stroke in particular is associated with a high mortality rate and a significant risk of severe long-term disability, greatly affecting patients’ quality of life while also imposing a substantial burden on families and society. The disease is influenced by the interaction of genetic, environmental and lifestyle factors. With the goal of analyzing the association between the MTHFR C677T gene polymorphism and ischemic stroke among patients treated at Thai Nguyen National hospital, A case–control study was conducted involving 150 patients with ischemic stroke and 150 control subjects without ischemic stroke, recruited at Thai Nguyen National hospital. The results showed that the MTHFR C677T polymorphic variant was relatively common in the study population, accounting for 40.7% in the case group and 17.3% in the control group. The CT/TT genotypes, the heterozygous CT genotype and the homozygous TT genotype of MTHFR C677T were associated with a 3.27-fold, 2.97-fold, and 5.57-fold increased risk of ischemic stroke, respectively, compared with the wild-type CC genotype. Individuals carrying the T allele had a 3.01-fold higher risk of ischemic stroke compared with those carrying the C allele. These findings indicate a statistically significant association between the MTHFR C677T polymorphism and the risk of ischemic stroke.Downloads
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