A PRELIMINARY STUDY ON FRONTAL LOBE CORTICAL THICKNESS USING MAGNETIC RESONANCE IMAGING IN ADULT VIETNAMESE MALES
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DOI:
https://doi.org/10.34238/tnu-jst.14525Abstract
Human aging is associated with progressive cognitive decline and structural brain alterations, particularly within the frontal lobe. This study aimed to investigate age-related changes in cortical thickness across frontal lobe regions. A cross-sectional study was conducted in 103 adult males stratified into three age groups at Thai Nguyen National Hospital between January and December 2025. Cortical thickness of frontal regions was quantitatively analyzed. The results demonstrated a progressive reduction in cortical thickness of the bilateral superior frontal gyrus, left rostralmiddlefrontal, left pars opercularis, bilateral pars orbitalis, bilateral pars triangularis, precentral gyrus decreased from the younger age group to the middle-aged group and was lowest in the elderly group, with p < 0.05. Age-related cortical thinning was region-specific and asymmetric, with a predominance of gray matter reduction in the left frontal hemisphere. The results of this study have initially contributed to building a scientific basis for referencing physiological brain aging, creating a foundation for future multimodal and longitudinal studies.Downloads
References
J. G. Hakun, Z. Zhu, C. A. Brown, N. F. Johnson, and B. T. Gold, “Longitudinal alterations to brain function, structure, and cognitive performance in healthy older adults: A fMRI-DTI study,” Neuropsychologia, vol. 71, pp. 225-235, 2015.
A. D. Singh, M. Kumar, B. H. Swathi, P. Bhargavi, A. Godbole, and S. Khushu, “Age-related cortical changes and cognitive performance in healthy adults,” Brain and Cognition, vol. 187, pp. 106-306, 2025.
S. Hu, J. S. Ide, H. H. Chao, B. Castagna et al., “Structural and functional cerebral bases of diminished inhibitory control during healthy aging,” Human Brain Mapping, vol. 39, no. 12, pp. 5085-5096, 2018.
J. M. Hyun, “The Relationship Between Lexical Performance and Regional Gray Matter Volumes: A Longitudinal Study of Cognitively Healthy Elderly,” Human Brain Mapping, vol. 39, no. 12, pp. 5085-5096, 2016.
A. M. Fjell and K. B. Walhovd, “Structural brain changes in aging: courses, causes and cognitive consequences,” Rev Neurosci, vol. 21, no. 3, pp. 187-221, 2010.
F. Gaspar‑Silva, D. Trigo, and J. Magalhaes, “Ageing in the brain: mechanisms and rejuvenating strategies,” Cellular and Molecular Life Sciences, vol. 80, no. 190, 2023, Art. no. 21.
D. H. Salat, R. L. Buckner, A. Z. Snyder, D. N. Greve, R. S. R. Desikan, and E. Busa, “Thinning of the cerebral cortex in aging,” Cerebral Cortex, vol. 14, no. 7, pp. 721-730, 2004.
N. Raz, U. Lindenberger, K. M. Rodrigue, K. M. Kennedy, D. Head, A. Williamson, and J. D. Acker, “Regional brain changes in aging healthy adults,” Cerebral Cortex, vol. 15, no. 11, pp. 1676-1689, 2005.
V. M. Dotson, S. M. Szymkowicz, C. N. Sozda, J. W. Kirton, M. L. Green, A. O’Shea, M. E. McLaren, S. D. Anton, T. M. Manini, and A. J. Woods, “Age differences in prefrontal surface area and thickness in middle aged to older adults,” Front Aging Neurosci, vol. 7, 2015, Art. no. 250.
C. D. Good, I. S. Johnsrude, J. Ashburner, R. N. A. Henson, K. J. Friston, and R. S. J. Frackowiak, “Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains,” NeuroImage, vol. 14, no. 3, pp. 685-700, 2001.
C. J. Tinsley, “ Editorial: Structural and Functional Organisation of the Prefrontal Cortex,” Front Syst Neurosci, vol. 10, pp. 1-2, 2016.
E. Koechlin, C. Ody, and F. Kouneiher, “The Architecture of Cognitive Control in the Human Prefrontal Cortex,” Science, vol. 302, no. 5648, pp. 1181-1185, 2003.
R. A. I. Bethlehem, J. Seidlitz, S. R. White, J. W. Vogel, K. M. Anderson, C. Adamson, and A. F. Alexander-Bloch, “Brain charts for the human lifespan,” Nature, vol. 604, pp. 525-533, 2022.
X. Di, B. Rypma, and B. B. Biswal, “Correspondence of Executive Function Related Functional and Anatomical Alterations in Aging Brain,” Neuropsychopharmacol Biol Psychiatry, vol. 48, pp. 1-26, 2014.
