Investigation of male Carica papaya L. flower infusion concentration on the gastric histology of mice

Abstract

This study aimed to investigate the effects of male Carica papaya L. flower infusion on the gastric histology of female mice induced with diabetes by streptozotocin. Diabetes was induced using streptozotocin (100 mg/kg BW) and nicotinamide (120 mg/kg BW). The experiment was conducted on 72 mice, divided into six groups, including control, diabetic model, and treatment groups receiving Metformin or male papaya flower infusion at two concentrations. The male papaya flower infusion was obtained via aqueous hydrolysis at 60°C and then diluted to concentrations of 12.4 and 22.22 mg/mL. The results showed that male papaya flower infusion (22.22 mg/mL) exhibits a gastroprotective effect in Streptozotocin-induced diabetic female mice, comparable to Metformin. This effect was observed through improved macroscopic morphology (reduced gas/fluid accumulation) and histological structure (increased mucosal proliferation, decreased cell degeneration). These findings provide a scientific basis for further investigation into the mechanisms and potential applications of Carica papaya L. male flower infusion in the adjunctive treatment of diabetes-related gastric pathologies.