IRIDOID GLUCOSIDES FROM Barleria lupulina LINDL.

DOI: 10.18173/2354-1059.2025-0007

Abstract

Four iridoid glycosides, 6-O-trans-p-coumaroyl-8-O-acetylshanzhiside methyl ester (1), 6-O-p-methoxy-trans-cinnamoyl-8-O-acetylshanzhiside methyl ester (2), 6-O-cis-p-coumaroylshanzhiside methyl ester (3), and ipolamiide (4) have been purified and structurally elucidated from Barleria lupulina Lindl. (Acanthaceae) collected in Luang Namtha province, Laos. Compound 1, at a concentration of 128 µg/mL, inhibited the growth of the A549 cancer cell line by 31% and nitric oxide production in RAW 264.7 cells by 30%. This is the first report on the chemical constituents of Lao’s Barleria lupulina.