Assessment of Alterations in Coagulation Parameters and Associated Factors in Breast Cancer Patients at Da Nang Oncology Hospital

Abstract

Background: Breast cancer is associated with coagulation abnormalities, increasing thrombotic risk and influencing disease progression. Understanding changes in coagulation parameters and their correlates is critical for patient management. Methods: A cross-sectional study was conducted from December 2023 to April 2024 at Da Nang Oncology Hospital, involving 105 female breast cancer patients. Platelet count (PLT), prothrombin time (PT), and activated partial thromboplastin time (APTT) were measured. Associations with age, disease stage (TNM classification), and metastasis status were analyzed using SPSS 20.0, with p < 0.05 considered significant. Results: PLT abnormalities occurred in 5.7% of patients, APTT in 1%, and PT showed no changes. Mean PLT was 254.4 ± 76.9 × 10⁹/L (range: 58–458 × 10⁹/L), APTT 24.2 ± 2.4 s, and PT 10.6 ± 0.7 s. PLT was significantly associated with age (p < 0.05), with a cutoff of >240 × 10⁹/L (AUC 0.67, sensitivity 68.2%, specificity 62.9%). No significant associations were found with disease stage or metastasis (p > 0.05). Conclusion: PLT decreases with increasing age in breast cancer patients, with a cutoff of 240 × 10⁹/L. Coagulation parameters remain largely within normal ranges, suggesting compensated hemostatic changes. Routine monitoring of PLT in older patients may aid risk stratification.