Synthesis of some derivatives of cycloart-23Z-ene-3β -25-diol and their bioacitivity

Abstract

Cycloart-23Z-ene-3β-25-diol was isolated from the leaves of Aglaia gigantea by bioassayguided fractionation. This compound showed very good cytotoxicity against human hepatoma (Hep-G2) and KB cells. In oder to investigate the relationship between biological activity and structure of the derivatives of cycioart-23Z-ene-3β-25-diol. we carried out synthesis of several new derivatives and examined their biological activities.