Effect of processing methods of Radix Polygalae on its sedative effects in experiment.

Abstract

    Radix polygalae has sedative, cognitive-enhancing, phlegm-dispelling, and detoxifying effects. However, its raw form may lead to gastric irritation and intestinal damage. Over time, R. polygalae has been processed using various methods to reduce toxicity and enhance therapeutic efficacy. According to the guidelines of the Ministry of Health of Viet Nam, R. polygalae is processed using two methods: bran-frying and licorice-frying. This study evaluated the effects of processing methods, as guided by the Ministry of Health, on the sedative effects of R. polygalae in experimental models. The sedative effects were assessed using the light-dark box and rotarod tests. The results showed that raw R. polygalae showed no sedative effects at the tested dose. The aqueous extracts of bran-fried and licorice-fried R. polygalae exhibited sedative effects at the same oral dose of 2.88 g of herb/kg. Both processing methods demonstrated comparable effects in the tested models. The enhanced sedative effects may be related to increased levels of saponins and tenuifolin after processing. Therefore, the processing methods significantly affect the sedative properties of R. polygalae. These findings provide evidence to optimize the clinical application of processed R. polygalae in anxiety management.