TOTAL SYNTHESIS OF ACETYL HEXAPEPTIDE-8 FOR USE IN COSMETICS

Abstract

Argireline is a short-chain peptide with anti-aging properties that reduce
wrinkles through a mechanism similar to Botulinum toxin. Currently, this
active ingredient is widely used as a cosmetic ingredient. However, despite its
high commercial potential, there have been no domestic publications related
to the synthesis of this active ingredient. Therefore, this study focuses on using
solid-phase peptide synthesis techniques to produce Argireline, followed by
confirming and evaluating the product's purity using high-performance liquid
chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-
MS). The results obtained show that the product has an average synthesis
yield of 38% with a purity of approximately 100%.