ANTI-INFLAMMATION ACTIVITY OF JATROPHA PODAGRICA HOOK EXTRACTS COLLECTING IN DONG NAI

Abstract

 Jatropha podagrica Hook. belongs to the Euphorbiaceae family, and has been traditionally used in folk medicine to alleviate constipation, skin infections, jaundice, and fever. This plant exhibits various pharmacological effects, including antibacterial, anticancer, antioxidant, insect growth inhibition, neuromuscular inhibition, and hypotensive properties. However, its anti-inflammatory activity remains unexplored. In this study, extracts from the leaves, stems, and roots of Jatropha podagrica were investigated using the RAW264.7 cells model, which was stimulated with lipopolysaccharide (LPS) to induce inflammation. The findings revealed that the ethyl acetate (EtOAc) fractional from Jatropha podagrica roots exhibited potent inhibition of nitric oxide (NO) biosynthesis, with an IC₅₀ value of 112.6 ± 8.5 µg/mL. Additionally, the EtOAc extract from Jatropha podagrica roots reduced the protein expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in protein expression models. These results suggest that extracts and fractions derived from Jatropha podagrica possess promising anti-inflammatory properties, highlighting their potential as valuable resources for the development of future anti-inflammatory drugs