CHEMICAL CONSTITUENTS FROM HEXAN EXTRACT OF MARINE SPONGE HYRTIOS ERECTUS

Abstract

Hyrtios erectus, a tropical marine sponge, from the genus Hyrtios (class: Demospongiae, Order: Dictyoceratida, Family: Thorectidae) is reported to contain a variety of secondary constituents including β-carboline alkaloids and terpenoids. These constituents exhibit diverse biological activities such as cytotoxicity, anti-inflammatory, antioxidant, antiphospholipase A2, and antibacterial, antidiabetic signals. Although the sponge H. erectus has medicinal potential, in Vietnam, there have not been many studies on this sponge. Therefore, studies have been conducted with the aim of investigating the chemical composition of H. erectus, in order to contribute, demonstrate and enrich the value of this sponge from marine sources. Through the method of normal-phase and reversed-phase silica gel column chromatography, combined with the method of thin-layer chromatography with other solvent systems. From the hexane extract, two pure compounds were isolated. From the 1D NMR and MS spectral data, combined with comparison with reference literature, the chemical structures of the two compounds were determined as (+)-curcudiol (1) and (+)- curcuphenol (2). Both compounds were isolated for the first time from H. erectus.