Factors affecting the morphology and size of silica nanoparticles as drug delivery for cancer treatment
Abstract
Currently, the use of nanoparticles as “carriers” to deliver drugs to the correct location has attracted the attention of scientists. Nano silica (SNs) is widely studied as material for biomedical applications. In this study, SNs particles were synthesized using the Stober method. The study investigated two factors affecting the morphology and particle size: reaction time and NH3 solution addition rate. Determining the characteristic properties of the material, methods used include transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and the N2 adsorption-desorption. SNs particles are spherical and highly homogeneous, with a 105.06 ± 0.74 nm size. The efficiency and loading capacity of Dox of SNs particles were 17.70 ± 0.52 % and 4.11 ± 0.11 %, respectively. The SNs/Dox drug carrier system has good potential for controlled drug release.
