NOVEL NANOSILICA ENCAPSULATED CURCUMIN AS WOUND HEALING AGENT

Abstract

Nanosilica (nano SiO₂) is the most widely-used single material in the field of science and technology. With its structural stability, lower toxicity and higher biocompatibility compared to other nanomaterials (gold nanoparticles, magnetic nanoparticles), nanosilica has the potential to enhance the biological activity, plays the role of adhesion hydrogel for soft tissue, and increases adhesion and proliferation of cells. The combination of curcumin and nano SiO₂ makes the nano SiO₂-curcumin dissolve better and increase the contacted area and preserve the biological activity of curcumin. In this study, the authors have evaluated the activity of nano SiO₂-curcumin in vitro fibroblast cell line and treatment of burn in Mus muscullus var. albino. The result have shown that at a concentration of 5%, nano SiO₂-curcumin results in better growth and development of fibroblast cell and reduces the time for burn treatment within 16 days compared to control groups which use only curcumin or nanosilica within 19 days.

Keywords: Curcumin, fibroblast, nanosilica, nano SiO₂-curcumin