EFFECTS OF EXTRACT CONDITIONS ON POLYPHENOLS AND FLAVONOIDS FROM THE EXTRACT OF COSTUS PICTUS D. DON LEAVES GROWN IN VIETNAM

Abstract

Costus pictus of Costacerace has many medicinal effects such as antioxidant, anti[1]cancer, antibacterial, anti-inflammatory, and anti-diabetic, etc. C. pictus was used to treat diabetic diseases in Ayurvedic traditional medicine of India. C. pictus has just been planted in Vietnam in the past few years. There have not been many studies screening bioactive ingredients and therapeutic effects in leaves C. pictus under growth conditions in Vietnam. The study aimed to investigate the effects of some extraction conditions on the contents of polyphenols and flavonoids in the leaf extracts. As a result, we obtained the highest content of polyphenols and flavonoids according to theoretical calculations in C. pictus leaves extract by cold maceration method with the following conditions: extraction solvent is ethanol 90%; material: solvent ratio is 1:50 (g/mL) in 48 hours of extraction time. At these conditions, the measured polyphenols and flavonoids were equivalent to 94.66 ± 0.85 mg GA/g dry weight and 38.49 ± 0.25 mg QE/g dry weight, respectively.