Evaluation of practice of postoperative thromboembolism prophylaxis among colorectal cancer patients in the National Cancer Hospital

Tóm tắt

The study was carried out to investigate the appropriateness of thromboprophylaxis for colorectal cancer patients after surgery. A descriptive retrospective study was conducted among patients aged 18 and above, who underwent colorectal cancer surgery at the Department of Internal Medicine, National Cancer Hospital from January 2021 to June 2021. Criteria for appropriate prophylaxis were set up based on the international and local thromboprophylaxis guidelines and anticoagulants’ summary of product characteristics (SmPC). The prophylaxis regimen of patients after 166 surgeries were evaluated. The major surgeries accounted for 92.8 % of the surgeries. The proportions of patients with high and moderate risks of postoperative venous thromboembolism (VTE) were 91% and 8 %, respectively. The rate of patients who received any form of thromboprophylaxis was 16.3% while the rate of patients indicated with appropriate methods of VTE prevention was 83.7%. The proportion of patients without prophylaxis was significantly higher among patients with moderate VTE risk compared to those at high risk (p=0.004). Among patients with appropriate thromboprophylaxis, 100% were prescribed an appropriate anticoagulant at a suitable dose.  However, all of them initiated the therapy later than the recommendations and 96.4% had shorter prophylactic duration. There was still a gap in the appropriate practice of post-surgical thromboprophylaxis for patients undergoing colorectal cancer treatment. The initiation time and the duration of prevention still deviated from the standard recommendations.