Các Triterpene khung Oleanan và Ursan từ vỏ cây Eberhardtia aurata (Sapotaceae)
Tóm tắt
In the framework of scientific cooperation between the Institute of Chemistry (VAST, Vietnam) and the Institute of Natural Product Chemistry (CNRS, France) on phytochemistry of the Vietnamese flora, the plant Eberhardtia aurata (Pierre ex Dubard) Lecomte was selected forits cytotoxic activity on KB cell lines (49% inhibition at 1 pg/mL for the EtOAc extract of the bark). From the EtOAc extract of the stem bark of this plant, 4 oleanane triterpenes, P-amyrin acetate (1), taraxerol (2), taraxerone (3), 3d-octacosanoyloxy-12-oleanen-28-ol (4) and 2 ursane
triterpenes, gamboukokoensein A (5) and myrianthic acid (6) were isolated. Their structures were elucidated by using IR, MS and NMR spectroscopic methods, including 2D NMR spectroscopy (COSY, HMQC, HMBC).