Circulation of foot and mouth disease virus and the levels of antibody in pigs and cattle after injection with FMD vaccine serotype O (>6PD50) in Tien Giang province

Abstract

The study was conducted to determine the circulation of foot-and-mouth disease virus (FMDV) in the pigs and cattle in Tien Giang province from 2016 to 2020 and to monitor antibody levels of these animals after injection with Aftopor monovalent O 6PD50 vaccine. The studied result showed that
FMDV in Tien Giang was associated with serotypes A and O; in which, serotype A was only detected in cattle (ASIA/Sea-97), serotype O was detected in both cattle and pigs. Among serotype O, we found 2 viral lineages in cattle (O/ME-SA/PanAsia and O/ME-SA/Ind-2001e) and 4 viral lineages
in pigs (O/Cathay, O/ME-SA/PanAsia, O/ME-SA/Ind-2001e and O/SEA/Mya-98). ELISA and virus neutralization on animal cells showed that 2-doses-injected pigs; 1-dose-injected sows and cows with aftopor monovalent O 6PD50 vaccine acquired 100%, 90% and 100% of seropositive samples with anti-FMDV antibodies, respectively. In the pigs, sows and cows, all protection rates were achieved higher than 93% for the lineage Ind-2001e, suggesting that this vaccine is highly effective to use for preventing FMDV in cattle and pigs in Tien Giang province.