Một số thành tựu trong nghiên cứu phát triển nền tảng chip vi lưu tập trung và phát hiện protein dựa trên kênh dẫn nano và cảm biến trở kháng

Abstract

Recent advances in microfluidic technology have significantly driven the development of protein detection methods, a critical technique for early diagnosis and effective treatment of diseases, particularly cancer. The combination of microfluidic systems with advanced sensing technologies not only reduces sample volume and analysis time but also significantly enhances the sensitivity, selectivity, and integration capability of detection systems. This study provides an overview and evaluation of recent achievements in enhancing microfluidic structures, combining nanochannel techniques with impedance sensors for protein detection. The proposed integrated microfluidic platform employs ion concentration polarisation (ICP) based on nanochannels for protein preconcentration, along with electrochemical impedance spectroscopy (EIS) to detect target proteins. This integrated approach improves sensitivity and specificity, offering an efficient solution for detecting low-concentration proteins in biological samples. By controlling ion concentration within the microfluidic channel and using impedance sensors on a lab-on-chip device, the reported results demonstrate the potential of a low-cost, efficient, and scalable diagnostic method with promising applications in point-of-care devices.