Influences of the filler excipients maltodextrin and silicone dioxide on the properties of the spray-dried extracts from Orthosiphon stamineus

Abstract

As spray-dried extracts of Orthosiphon stamineus showed moisture- sensitive, poor flowability and poor compressibility, the effects of maltodextrin and silicone dioxide on the properties of  the spray-dried extracts of O. stamineus  were investigated. Four spray-dried extracts were prepared from concentrated liquid extracts as follows: Spray-drying the original concentrated liquid extracts; adding silicone dioxide (SD) at the ratios of 15 % or 30 % (w/w) or maltodextrin (MAL) 30 % (w/w) to the concentrated liquid extracts, well mixing and then spraying. All the four obtained samples were examined and evaluated for particle morphology, hygroscopicity, flowability (angle of repose, flow rate, Carr’s Index, Hausner ratio), and compressibility. Addition of SD (15 - 30 %) and Mal to the extracts proved no significant improvement of the extract properties in view of high hygroscopicity, poor flowability and low compressibility, but the best improvevement was achieved by adding SD 30 % to the concentrated liquid extracts before spraying, getting desirably low hygroscopicity, good flowability and good compressibility. Thus, these may serve as potential materials for preparation of the extracts and production of related products.