Biocompatible thin films based on ZIF-8 and applying for Tetracycline delivery

Tóm tắt

New classes of thin films: ZIF-8, mesoZIF-8 and TiO₂@ZIF-8 grated on biocompatible polymers including chitosan (CS) and polyetilene glycol (PEG) were fabricated. The films were carried out in green conditions to apply for drug delivery study. The combination of two polymers PEG and CS enhanced the bonding with the ZIF-8 framework since many function groups have formed in a slightly acidic solution. The resulting of materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), which revealed the ZIF-cooporated on the polymers well. For the first time, the examination of tetracycline (TC) delivery was studied on these hybrid thin films. The TC delivery was showed in high effective by using the film compared to several materials.