Treatment results of differentiated thyroid cancer with lung metastasis using I-131 at Nghe An Oncology Hospital

Abstract

Objective: Evaluate the treatment results of differentiated thyroid cancer (DTC) with lung metastasis using I-131 at Nghe An Oncology Hospital.
Methods: A retrospective and prospective descriptive study of 45 DTC patients with lung metastasis diagnosed by whole-body scintigraphy and to evaluate the treatment results with I-131 at the Department of Nuclear Medicine, Nghe An Oncology Hospital from January 2018 to May 2024.
Results: DTC patients with lung metastasis had an average age of 47.26 ± 15.75 years old, with a male-to-female ratio of 1/2.5. The pathological type was mainly papillary with a rate of 93.3%. The average thyroglobulin level at the time of stopping the drug was 112.32 ± 154.7 ng/ml. The lesions on whole-body I-131 scan were mainly diffuse hyperactivity with a rate of 77,8%. Patients were treated multiple times with I-131, an average of 3.75 times and had a total cumulative treatment dose of 540 ± 193,73 mCi (150-970). The rate of complete response to I-131 accounted for 17.8%. The rates of incomplete and indeterminate responses were 64.44% and 17.8%, respectively. Age and thyroglobulin stimulation were two valuable factors in predicting the response to I-131 treatment in DTC patients with lung metastases.
Conclusion: DTC patients with lung metastasis treated with I-131 at Nghe An Oncology Hospital had a complete response rate of 17.8%, incomplete and undetermined response rates of 64.44% and 17.8%, respectively.