STUDY ON FORMULATION AND EVALUATION OF BURN REMOVAL CREAM FROM ALOE VERA L., CENTELLA ASIATICA URB., COPTIS CHINENSIS FRANCH

Abstract

Burns are a common accident in human life, in labor and in entertainment. Currently, there are many drugs used to treat burn wounds on the spot which are produced domestically or imported from abroad. The herbal plants with the effect of treating burns are growing widely in Viet Nam but their use is still limited. The research and manufacture of new drugs from available materials in the country, abundant reserves, low cost and effective treatment in place of burn wounds has always been set out in the treatment of burns. The research results have built a cream formulation containing 42% high extract content (14% Aloe vera extract, 14% Centella asiatica extract, 14% Coptis chinensis extract); smooth sensory properties, homogeneity without separation; The cream penetrates deeply into the skin, averaging 9.0 ± 0.61 mm, and a pH of 6.0 to 6.5. Initial evaluation of the stability of the cream shows that: the cream is stable under mechanical action at the time of research. Test results for treatment of second-degree burns in lab mice showed clear effects, no dead mice, fast recovery skin after 7 days of application.